Hepaza -

Hepaza

HEPAZA is a dietary supplement that supports and regenerates human liver and gall in the following conditions – intoxications, chronic inflammatory processes, liver cirrhosis, steatosis, etc.

HEPAZA can also be used as a protection against liver damage in case of excessive use of alcohol, unhealthy diet and liver-damaging medicines; continuous working in a toxic environment, etc.

Each HEPAZA tablet contains:

dry extract of milk thistle seeds, cont. Silymarin

choline bitartrate, cont. choline

Indications

Silymarin may increase serum insulin levels and reduce blood sugar levels.
It may increase the levels of antioxidant enzymes and glutathione, as well as restore pancreatic endocrine function in experimental diabetes models
It improves pancreatic function after exposure to damaging effects of toxic agents

Warnings

In case of diseases related to hormonal disorders - tumors of the uterus, ovaries or breast, prostate tumors, prior consultation with a doctor is necessary before taking HEPAZA.
The product may reduce the effectiveness of oral contraceptives and tamoxifen.
HEPAZA may enhance the effects of drugs such as diazepam, alprazolam, ketoconazole, lovastatin, atorvastatin, vinblastine when used simultaneously with them.
Do not exceed the recommended daily dose without the advice of a doctor. The product is not suitable for children under 12 years of age.

Take HEPAZA twice daily, one tablet during each meal. The tablets are taken whole, with sufficient amount of water.

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Fibrosis and Cirrhosis

Liver cirrhosis is a chronic diffuse liver damage with a progressive course. Fibrosis and cirrhosis of the liver are considered separate stages of the same process. Liver damage is characterized by:
- Cell death;
- Liver fibrosis and proliferation of connective tissue;
- Nodular formations, as a result of which the normal arrangement of organ structures and blood supply are disrupted.

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Hepatic Steatosis, also known as Fatty Liver

- It is a change in the structure of liver tissue, in which there is an accumulation of fat cells in the liver.
- It is caused by a number of factors, among which the most important are: consumption of foods and beverages rich in sugars and fats, insufficient physical activity, obesity, the presence of diabetes, alcohol abuse, certain medications, toxins, etc.

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Diseases that require liver support and regeneration:

- toxic liver damage;
- conditions after hepatitis;
- chronic hepatitis of non-viral origin;
- fatty degeneration of the liver;
- liver cirrhosis;
- alcoholic cirrhosis.

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Cases requiring liver damage prevention:

- prolonged use of medications

- regular alcohol intake

- chronic intoxication (including occupational).

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Silymarin

Milk thistle (Silybum marianum) has been used in medicine for 2000 years, mainly for the treatment of liver and biliary diseases.
The active component is the flavonoid complex silymarin. It can inhibit the synthesis of 5-lipoxygenase (which is involved in the formation of free radicals), scavenge hydroxyl radicals and suppress tumor necrosis factor (TNF).

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The different mechanisms of silymarin influence are, as follows:

- Increasing the regenerative capacity of liver cells by enhancing the synthesis of DNA and RNA, since silymarin has a steroid structure;
- Changing the structure of the outer membrane of the hepatocyte, which prevents the entry of xenobiotics into the cell (poisoning with the Amanita mushroom is a striking example of such a mechanism);
- Removing free radicals and increasing the cellular content of glutathione, which leads to inhibition of lipid peroxidation.

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Choline (Vitamin B4) plays a key role in DNA synthesis and maintenance of cell membranes. It stimulates cell regeneration, fat metabolism and stimulates the metabolism of HDL ("good") cholesterol.
Choline has a protective effect on the liver, preventing steatosis and lowering triglyceride and cholesterol levels. Choline helps reduce liver damage caused by hepatitis or alcohol use.
Choline also contributes to the regulation of gallbladder function.

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A diet rich in Choline, results in lower levels of the important inflammatory markers: C-reactive protein, homocysteine, IL-6 (interleukin 6) and TNF (tumor necrosis factor), which leads to lower cardiovascular risk.

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